HerbClinical dose · 140–300mg/day (standardised to >60% mangiferin)Onset · 1–2 hours (acute)

Zynamite (Mangifera indica)

Name: Zynamite (Mangifera indica) — Human Clinical Effect Matrix
Creator: The Nootropic Lab
License: https://creativecommons.org/licenses/by/4.0/

A 2020 RCT (Lopez et al.) found 300mg Zynamite acutely improved reaction time, attention, and working memory versus placebo. A 2019 sports performance study showed Zynamite + luteolin (Dynamine) improved repeated sprint performance and cognitive function under physical fatigue. Evidence base is small but growing — Nektium (the manufacturer) funds most research.

By The Nootropic Lab editorial teamUpdated Sep 9, 20268 min read✓ Fact-checked

Mechanism of action

Zynamite is a patented extract of Mangifera indica (mango leaf) standardised to >60% mangiferin. Mangiferin is a potent polyphenol that inhibits catechol-O-methyltransferase (COMT), slowing the breakdown of dopamine and norepinephrine in the prefrontal cortex. This extends the active duration of catecholamines without increasing their production — a unique mechanism distinct from precursor-loading (L-Tyrosine) or synthesis-boosting (caffeine) approaches. Additionally, mangiferin has anti-inflammatory and antioxidant properties.

Clinical evidence summary

Human effect matrix

Based on human clinical trials only. Animal and in-vitro data excluded.

Effect	Evidence	Magnitude	Studies	Notes
Reaction Time	moderate	Moderate	2	Lopez et al. (2020) showed significant improvement in choice reaction time at 300mg. Acute onset within 1 hour.
Working Memory	preliminary	Small	2	Modest improvements on n-back tasks. More research needed to confirm effect size.
Physical-Cognitive Dual Task	preliminary	Moderate	1	Maintained cognitive performance during physical fatigue (sprint protocol). Novel finding but single study.

Evidence key: Strong = multiple consistent RCTs · Moderate = smaller/fewer RCTs · Preliminary = early trials or small n · Mixed = conflicting results

Documented benefits

Extended dopamine activity
Improved reaction time
Cognitive support under fatigue
Anti-inflammatory

Side effects & cautions

Generally well tolerated
Mild GI discomfort rare
Limited long-term safety data
Possible interaction with MAO inhibitors

How to take

Dosage140–300mg/day

TimingMorning or 1 hour before demanding cognitive/physical tasks.

With foodCan be taken with or without food.

FormsCapsule. Zynamite is the only clinically studied mangiferin extract — generic mango leaf products are not equivalent.

Stacking recommendations

Ingredients that pair well with Zynamite (Mangifera indica) and why.

Caffeine

Caffeine increases catecholamine release; Zynamite slows their breakdown via COMT inhibition. Together they produce a stronger, longer-lasting dopamine signal.

L-Tyrosine

Tyrosine provides dopamine precursor; Zynamite slows dopamine metabolism. Supply + preservation for sustained catecholamine levels.

L-Theanine

L-Theanine smooths out any overstimulation from Zynamite's catecholamine-preserving effects. Balanced energy without agitation.

Frequently asked questions

Is Zynamite just mango leaf extract?

Zynamite is a specific patented extract of Mangifera indica standardised to >60% mangiferin. Generic mango leaf supplements may contain far less mangiferin and are not equivalent. The clinical trials used Zynamite specifically.

Is the evidence independent or manufacturer-funded?

Most Zynamite studies are funded or co-funded by Nektium, the manufacturer. This is common for patented ingredients but means independent replication is limited. The existing trials are well-designed (double-blind, placebo-controlled) but should be interpreted with this funding context in mind.

Can I take Zynamite with caffeine?

Yes — this is actually one of the studied combinations. Zynamite + caffeine showed synergistic effects on reaction time in the sports performance trial. However, monitor your total stimulant load since Zynamite extends catecholamine activity.